Hormone Replacement Therapy (HRT) May Combat Lung Function Decline in Women

Why Hormone Replacement Therapy May Be Safer Than You Think

Why Hormone Replacement Therapy May Be Safer Than You Think

Taking hormone therapy to treat menopausal symptoms like hot flashes does not increase a woman's risk of early death, according to a long-term follow-up of trials that were stopped early due to health concerns. The study was halted in 2002, after investigators found the hormone therapy appeared to put women at greater risk of invasive breast cancer, strokes and heart disease.

The door may be opening again for menopausal women suffering from hot flashes and night sweats to receive some relief from a source once thought too unsafe to consider, researchers say.

"All-cause mortality provides a critically important summary measure for an intervention such as hormone therapy that has a complex matrix of benefits and risks", stated JoAnn Manson, MD, DrPH, lead author and Chief, Division of Preventive Medicine at BWH.

Experts said the hormone therapy is safe to use by women who are looking to relieve symptoms from menopause such as hot flashes. They were followed for 18 years and tracked for chronic diseases like cancer, as well as heart attack and deaths.

Follow-up trials were conducted 18 years later by the Women's Health Initiative involved most of the more than 27,000 women aged 50-79 years who were part of the original research.

"It's the ultimate bottom line".

Brands studied were Prempro estrogen-progestin pills and Premarin estrogen-only pills.

The landmark research, backed by the USA government, began in the early 1990s to rigorously test hormones' effects in older women randomly assigned to take the pills or dummy treatment.

The results from this original research led to advice for women to not take the hormones for risk them causing heart disease, cancer or premature death.

Overall, nearly 7,500 women died - about 27 percent each in the hormone and dummy pill groups. During the follow-up, 7,489 deaths occurred, more than twice as many deaths as were included in earlier reports that had shorter follow-up periods.

Women who took estrogen for an average of seven years or combination estrogen and progesterone therapy for an average of five years had no increased risk of death after 18 years of follow-up, compared with women given an inactive placebo, the researchers found.

Overall, death rates were similar among women on both types of hormone treatment versus dummy pills. "In clinical decision making, these considerations must be weighed against the impact of untreated menopausal symptoms that women experience, including impaired quality of life, disrupted sleep, reduced work productivity and increased health care expenditures".

More research is necessary on the long-term benefits and risks of newer hormone therapies, the researchers say.

Notícias recomendadas

  • European Union seeks to ramp up North Korea sanctions pressure

    European Union seeks to ramp up North Korea sanctions pressure

    North Korea was condemned globally for its latest nuclear test on September 3, which it said was of an advanced hydrogen bomb. This is likely to hit the funding of its nuclear programmes.
    Shinzo Abe's approval rating recovers after North Korea test

    Shinzo Abe's approval rating recovers after North Korea test

    A vegetarian Gujarati platter awaits the Japanese prime minister and his wife at Ahmedabad's popular terrace restaurant, Agashiye. PM Modi will be accompanying the visiting leader and his spouse Akie Abe to explain the cultural significance of the mosque.
    Kylian Mbappe Reportedly Almost Kicked by Fan During Celtic vs. PSG

    Kylian Mbappe Reportedly Almost Kicked by Fan During Celtic vs. PSG

    PSG host Bayern Munich in what promises to be a more severe test of their credentials. This is published unedited from the PTI feed.
  • Jean-Claude Van Damme's son arrested for assault

    Jean-Claude Van Damme's son arrested for assault

    According to TMZ's account , police arrived on the scene and discovered a trail of blood leading to Van Varenberg's apartment. His bond was originally set at $10,000, but it is unknown how much bond was posted upon his release.
    Myanmar: UN: 310000 Rohingya Muslims flee, textbook example of ethnic cleansing

    Myanmar: UN: 310000 Rohingya Muslims flee, textbook example of ethnic cleansing

    The Rohingya minority community has always been subjected to discrimination in Myanmar, which denies them citizenship. They urged the worldwide community to provide security to the Rohingya Muslims who are facing systematic genocide.
    De Blasio secures Democratic nomination in mayor's race

    De Blasio secures Democratic nomination in mayor's race

    In Brooklyn, acting District Attorney Eric Gonzalez defeated a crowded field of candidates to remain the borough's top prosecutor. For the City Council District 43 seat, Justin Brannan won the Democratic nod and John Quaglione won the Republican primary.
  • Hurricane Warning Issued for Mexico as Katia Nears

    Hurricane Warning Issued for Mexico as Katia Nears

    As for the three storms now occupying the Atlantic and Gulf of Mexico , all three are expected to take very different paths. ET on Wednesday, Jose was moving west at 16 miles per hour , and the NHC expects that to continue over the next two days.
    5 men missing after early morning maritime collision

    5 men missing after early morning maritime collision

    The maritime authority has told ships to look out for the missing crew and to navigate with caution near the collision site. The partially submerged dredger was moved safely to an area near Pulau Sepang for underwater search operations.
    House OKs measure condemning white nationalists

    House OKs measure condemning white nationalists

    Mark Warner and Tim Kaine , of Virginia, had introduced the measure along with four colleagues from both parties. The resolution will go to the House next, where identical language has been introduced.
  • Rain, wind continues through Tuesday morning

    Rain, wind continues through Tuesday morning

    It is expected to make landfall around Tampa as a Category 1 Hurricane with a wind speed of 90mph Monday morning . However, it will be of little effect in our area outside of some spotty showers Wednesday and Thursday.
    Nintendo To Revive Sold Out NES Classic Edition

    Nintendo To Revive Sold Out NES Classic Edition

    Next summer, Nintendo will also bring back the Nintendo Entertainment System: NES Classic Edition system with new shipments.

    John McCain to N Korea: Aggression will lead to 'extinction'

    It also calls for the resumption of Six-Party talks that lead to the complete denuclearization of the Korean Peninsula. Beijing believes Thaad , which employs a powerful radar, is a security threat to China and neighbouring countries.

We are pleased to provide this opportunity to share information, experiences and observations about what's in the news.
Some of the comments may be reprinted elsewhere in the site or in the newspaper.
Thank you for taking the time to offer your thoughts.