Glycemic Control Up With Oral Semaglutide in Type 2 Diabetes

A type 2 diabetes pill taken once a day has been shown to "significantly" improve the health of people with the condition, according to new research.

This new observational study looked at the impact of different HbA1c levels and drug treatment regimen on the risk of first hospitalisation for heart failure and death in people with and without type 2 diabetes.

Although there are several type 2 diabetes treatments now available, many of them come with greater risks of developing low blood sugar, a condition known as hypoglycaemia, as well as weight gain. Semaglutide works by stimulating insulin production and suppressing the secretion of the glucose-raising hormone glucagon as well as lowering appetite. 71% of the 632 patients in the study were able to loose weight test results revealed.

The findings indicated that among patients with type 2 diabetes, the drug semaglutide taken by pill resulted in better glycemic control than placebo over 26 weeks.

"We know that it is a bit of a barrier to people and anything that makes treatment more accessible and easier has got to be seen as good".

The researchers found that there were decreases in the mean change in HbA1c level from baseline to week 26 with oral semaglutide (dosage-dependent range, -0.7 to -1.9 percent), subcutaneous semaglutide (-1.9 percent), and placebo (-0.3 percent); oral semaglutide reductions were significant compared with placebo. "Type 2 diabetes is a serious condition with potentially devastating complications which is posing a major challenge to health services across the world because of the increasing numbers of people developing it", Professor Davies told the Daily Mail.

Clinically relevant (five percent or more) weight loss was achieved in up to 71 percent of patients receiving oral semaglutide. Based at Leicester General Hospital, it is a partnership between the University Hospitals of Leicester NHS Trust and the University of Leicester.

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