Here's How a High-fat Diet May Facilitate Weight Loss

Research Having high-fat foods can actually help you to weight-loss

Research Having high-fat foods can actually help you to weight-loss

A cheery amazement for the people wishing to eat fatty diets and lose weight, simultaneously, as a team of scientists have recognized a way to prevent fat cells from developing larger, which leads to obesity and weight gain.

According to the Washington University School of Medicine, that the team bred mice with genes that would turn on this pathway in the creature's fat cells when it ate a lot of fat. For this project, the researchers manipulated something called the Hedgehog pathway, a signaling system that's involved in cell development throughout the body, and they say it was successful at "suppressing obesity" in mice, representing a possible pharmaceutical route for the weight condition. While these mice did not balloon on such a diet, the control mice without the special genes did become obese. The findings revealed that after about eight weeks of eating the high-fat diet, control animals whose Hedgehog pathways had not been activated became obese.

The Hedgehog pathway prevented obesity by inhibiting the size of the fat cells.

They explained that fat gain is due mainly to increased fat cell size and each fat cell grows bigger so that it can hold larger fat droplets.

When the fat cells begin to expand, that is when the person tends to gain weight- as opposed to having more fat cells.

By stimulating Hedgehog and related proteins in fat cells, the researchers kept the animals' fat cells from collecting and storing fat droplets.

It will take some work to make the mouse method work for humans, who also have Hedgehog pathways, but "this could lead us to a new therapeutic target for treating obesity", Long said. "If we can come up with strategies to carefully target fat cells, then I think activating this pathway could be effective in the fight against obesity", he said. People with obesity have an increased risk for stroke, heart attack, diabetes and cancer.

The research appears in the journal eLife.

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