Male fertility at risk from regular dose of ibuprofen

Ibuprofen male infertility issue joins cardiac risk as painkiller concerns grow

Ibuprofen male infertility issue joins cardiac risk as painkiller concerns grow

Men who took 600mg every day - the equivalent of three over the counter pills - were found to have a condition called "compensated hypogonadism" where testosterone levels fall to an worrying level, which may impact fertility.

"Concern has been raised over declining male reproductive health in humans", said lead author David Kristensen, of the University of Copenhagan, in the journal PNAS. "These compounds are good painkillers, but a certain amount of people in society use them without thinking of them as proper medicines".

The ibuprofen affected the production of hormones such as testosterone. Levels of luteinising hormone, which stimulates the production of testosterone, increased as they took the drug but overall levels of testosterone dropped.

"In the living body the pituitary gland kicks in to compensate for this, but the brain is pushing more to get the same amount of testosterone", said Kristensen. "If you go on and stress the pituitary gland over the long term, this state could become permanent and you develop a more serious condition".

The researchers said normal short-term use of ibuprofen shouldn't pose a risk. "Based on these data, I personally would be very reluctant to take ibuprofen for longer than the 10 days normally indicated on the packet".

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