Ketamine 'shows promise' in treatment of depression, study claims

Ketamine 'shows promise' in treatment of depression, study claims

Ketamine 'shows promise' in treatment of depression, study claims

Findings were published from the first study by a drug company to examine ketamine as a treatment option for depression.

Ketamine is a medication mainly used for starting and maintaining anesthesia.

Now, after a number of trials, researchers at Janssen Research and Development in New Jersey and the Yale School of Medicine determined that ketamine could be an effective treatment for depression, too. Patients who are also at risk of suicidality were randomly assigned to receive Ketamine or a placebo nasal spray twice a week for a period of four weeks.

Ketamine can mitigate major depression and suicidal thoughts, according to a USA study. Patients of the other group were given a placebo spray, created to not have any effect.

"The interesting USA study confirmed the findings from successful studies into intravenous ketamine", said Dr James Stone from Royal College of Psychiatrists, "The main reason for its significance is because this is being developed by a drug company and it's potentially quite likely that this medication might become available as a treatment available on the NHS for depression".

MJ_Prototype via Getty Images The nasal spray could provide rapid treatment for patients who are deemed at imminent risk for suicide.

Although the boost wore off over time - after 25 days, both groups were in a similar condition - the rapid effects of the ketamine spray indicate that it could be particularly beneficial for patients at risk of suicide, especially as most conventional antidepressants take four to six weeks to reach their full effect. Patients who received esketamine showed significantly greater improvement in suicidal thoughts at 4 hours (effect size = 0.67), but not at 24 hours after the first dose (effect size = 0.35) or at day 25 (effect size = 0.29). In the editorial, AJP Editor Robert Freedman, M.D., along with members of the AJP Editorial Board, note the known potential for abuse and existing reports of abuse of prescribed ketamine. That caution is also the focus of an accompanying AJP editorial also published online today. They discuss the need for additional research relating to the abuse potential of ketamine during phase 3 trials, such as monitoring of patients' craving and potential ketamine use from other sources.

Recommendations and plans have been put forward for further research to understand the potential for ketamine abuse during the third phase of trials.

The editors added that steps should be taken to make sure ketamine-based treatment will "continue to be available to those with need, while the population that is at-risk for abuse is protected from an epidemic of misuse".

Notícias recomendadas

  • Beyonce's Coachella set includes Destiny's Child reunion

    Beyonce's Coachella set includes Destiny's Child reunion

    Beyonce , who enjoys an incredible fan-base all over the world, was supposed to be the star performer at Coachella 2017. The audience has already started counting days but for now watch the best moments of Beyonce at Coachella .
    Avenfield case: Maryam's counsel cross-examines Wajid Zia

    Avenfield case: Maryam's counsel cross-examines Wajid Zia

    Later, the JIT head informed the court that the BVI officials had sought more information through e-mail to answer MLA. The witness also stated that he can not say in whose name bearer shares were issued after their cancellation.
    Woolworths hit by nationwide technical outage

    Woolworths hit by nationwide technical outage

    INITIAL: MAYHEM has erupted at Woolworths stores across the Mackay region as a national technical outage shuts down stores. A technical issue has forced Woolworths shops across Australia to close.
  • Kanye West shares memory of Lamar amid Khloé's drama

    Kanye West shares memory of Lamar amid Khloé's drama

    He made his first public appearance alongside West at his February 2016 Yeezy Season fashion show release party in NY . Meanwhile, Odom wasn't the only estranged Kardashian family member to get a shout-out on West's Twitter account.
    Inmates Killed, 17 More Injured, in South Carolina Prison Violence

    Inmates Killed, 17 More Injured, in South Carolina Prison Violence

    In a statement, SCDC Police Services and the South Carolina Law Enforcement Division said they will be investigating the incident. At least seven inmates are dead following a major incident at a prison in SC .
    WPI inflation eases marginally to 2.47% in March

    WPI inflation eases marginally to 2.47% in March

    However, the price of raw silk, mesta and hides, sunflower, soyabean, fodder, raw wool, coir fibre and raw rubber all moved up. It revised downwards forecast for retail inflation to 4.7-5.1 per cent for April-September and 4.4 per cent for October-March.
  • Bristol Topples After Merck Treatment Outperforms It In Lung Cancer Tests

    Bristol Topples After Merck Treatment Outperforms It In Lung Cancer Tests

    Bristol-Myers said in February that the trial succeeded, but didn't provide specifics. Herbst, head of oncology at Yale Cancer Center in New Haven, Connecticut.
    Kim Jong-un recebe delegação chinesa, em nova mostra de aproximação

    Kim Jong-un recebe delegação chinesa, em nova mostra de aproximação

    Kim vai ser o primeiro dirigente norte-coreano a pisar solo da Coreia do Sul desde o fim da Guerra da Coreia (1950-53).
    Eurovision star Conchita Wurst reveals HIV diagnosis

    Eurovision star Conchita Wurst reveals HIV diagnosis

    M - Eurovision victor Conchita has told fans that she is HIV-positive, and has been in regular treatment for "several years". However, the singer added: "Coming out is better than being outed by third party".
  • Tropicana Entertainment to sell property, merge casino operations

    In light of these risks, uncertainties and assumptions, the forward-looking events discussed in this press release may not occur. Initial annual rent is $110 million and the rent coverage is expected to be not less than 1.85 times as defined by the lease.

    US Retail Sales Climb More Than Expected On Rebound In Auto Sales

    The report said retail sales climbed by 0.6 percent in March after edging down by 0.1 percent in February. Total sales for the January 2018 through March 2018 period were up 4.1% from the same period a year ago.

    James Harrison Announces 'Final' NFL Retirement In Definitive Instagram Post

    Be sure to do an extra bench press and set of leg squats for James Harrison on Monday. He is the Steelers' all-time sack leader.

We are pleased to provide this opportunity to share information, experiences and observations about what's in the news.
Some of the comments may be reprinted elsewhere in the site or in the newspaper.
Thank you for taking the time to offer your thoughts.