"Measles" Wipes Your Immune System's Memory, So It Can't Fight Other Infections

"Measles" Wipes Your Immune System's Memory, So It Can't Fight Other Infections

As the number of measles cases rises in the U.S, research reveals a new way the disease can leave patients vulnerable to future infections.

Measles infections can wipe out a baby's immune system for up to 5 years - resetting it to a baby-love mutter, a detect suggests. The discoveries additionally fill in as an update that the current year's record-breaking measles flare-ups in the USA will have waiting impacts, Schaffner included.

Pneumonia affects one in 20 children with measles, while others suffer risky stomach bugs and one in ten get ear infections which can lead to permanent hearing loss.

Using a special blood test the researchers looked at the antibodies in children before and after natural infection with measles virus as well as in children before and after measles vaccination.

When Kula examined an initial set of these samples, he found a striking drop in antibodies from other pathogens in the measles-infected children that "clearly suggested a direct effect on the immune system", the authors said.

Prof Mina and colleagues found those who survive measles gradually regain their previous immunity to other viruses and bacteria as they get re-exposed to them.

As such, geneticist Stephen Elledge of Harvard Medical School told NPR we should think of the measles vaccine "like a seat belt for your immune system". However, precisely how post-measles immune suppression unfolds in humans is unknown. As a result, some Americans still view measles as relatively harmless-which, in addition to a unsafe uprising of anti-vaccine sentiment, has led some parents to decline shots for their children, contributing to a resurgence of preventable illness in the USA and overseas.

If parents elect not to vaccinate their children against measles, they are not only risking a one-time battle with a disease... they're also risking crippling their child's immune system and preventing them from fighting off diseases they had already built immunity against.

The findings explain why children often succumb to other infectious diseases after they have had measles and highlights the importance of getting vaccinated. "It's much more risky to children who get it, not only when they get it but for years afterwards".

The researchers sequenced antibody genes from 26 children, before and 40-50 days after their measles infection. "These two papers complement each other in an interesting way, and they both provide clues to help answer how measles causes immune damage".

After catching the virus, children lost between 11% and 72% of their total antibody diversity, indicating that measles had partially wiped their immune memory. Which cells in the body to have a yeast infection and used later, to create a new infection to deal with. Tomasz Kula, a postdoc in Elledge's lab, had developed a technology called VirScan that enabled the team to test the antibodies in the infected children's blood against antibody targets representing most known human pathogenic viruses.

This means that measles can effectively undo the protection provided by vaccines against other infections like flu or even tuberculosis - and measles outbreaks can thus cause spikes in other illnesses.

The measles virus is highly contagious and causes coughing, rashes and fever, and can lead to potentially fatal complications including pneumonia and encephalitis, leading to more than 100,000 deaths per year worldwide in unvaccinated communities.

Since measles figures have experienced a rebound in recent years due to the decline in vaccination - when both doses protect 99% against infection -, and the World Health Organization (WHO) has warned of a new The epidemic wave in countries such as the United Kingdom, Greece, Albania and the Czech Republic, this work is especially relevant. "Ultimately, the conclusions that can be drawn are very similar: Infection really skews the naive repertoire, and you could expect that that would have long-term, downstream consequences on immune memory", Mina says. For most of the population, this erasure is temporary, and after a few months, people recover lost antibodies. Some of the authors also serve as advisers to vaccine makers. "It's like taking somebody's immune system and rewinding time, putting them at a more naïve state", Mina says.

Follow-up animal research showed that measles reduced the level of flu antibodies in ferrets that had been vaccinated against influenza, the report said. "Hopefully these families will be willing to continue to be involved with the researchers", he says.

Notícias recomendadas

  • Drake signs up for Toronto marijuana venture

    Drake rapped about starting from the bottom, but his new venture in the cannabis industry is certainly a higher business. The trademark was filed on October 21 and the applicant is listed as Dream Crew IP in West Hollywood, Calif.
    First Trailer For Vanessa Hudgens' 'The Knight Before Christmas' Is Here

    First Trailer For Vanessa Hudgens' 'The Knight Before Christmas' Is Here

    The Knight Before Christmas hits Netflix on November 21, but in the meantime, you can check out the trailer below. The film was written by Cara Russell.
    Billie Eilish has a mullet now and she highkey pulls it off

    Billie Eilish has a mullet now and she highkey pulls it off

    The "Bury A Friend" singer attracted attention for her edgy new 'do at the LACMA Art + Film Gala on November 2. And so, when Billie debuted a mullet on the red carpet for the LACMA Art + Film Gala, it was not deliberate.
  • 37 killed in Burkina Faso's deadliest attack in five years

    37 killed in Burkina Faso's deadliest attack in five years

    Increased bloodshed has forced hundreds-of-thousands of people to flee their homes, igniting a fast-growing humanitarian crisis. It was unclear exactly how many people were in the convoy, what their nationalities were or how many were missing.
    US scientists identify new HIV strain, first in nearly 20 years

    US scientists identify new HIV strain, first in nearly 20 years

    When it comes to HIV-1, there are four different groups: Group M , Group N, Group O, and Group P. Rodgers explained that these two cases were unusual and "didn't match other strains".
    Fired McDonald's CEO could pocket $70M payout after co-worker affair

    Fired McDonald's CEO could pocket $70M payout after co-worker affair

    Policies which require executives to hold shares are used to tie leaders' personal wealth to shareholders' interests. McDonald's is seen late in reintroducing chicken sandwiches and rival Wendys Co has started serving breakfast.
  • Climate change education enforced in Italian schools by September 2020

    Climate change education enforced in Italian schools by September 2020

    With this, the Italian education system will be the first system that puts the environment and climate first before anything else. The whole education ministry will now be dedicated to climate change education and sustainable development.
    Presidents Cup: Meet Tiger Woods and Team USA

    Presidents Cup: Meet Tiger Woods and Team USA

    Day has dropped to world No.27 after a winless year and has a poor Presidents Cup record of five wins and 11 losses. Woods was introduced as captain in March 2018, when he was just returning from a fourth surgery on his lower back.
    Ben Simmons Exits Game With Shoulder Sprain

    Ben Simmons Exits Game With Shoulder Sprain

    Simmons will sit out against Denver and will be evaluated again before Sunday's (next Monday, PHL time) game against Charlotte. Simmons did not play in the second half after bumping into Royce O'Neale's chest while posting up on a first-quarter play.
  • Meryl Streep, Lin-Manuel Miranda, Emma Stone to Host 2020 Met Gala

    Meryl Streep, Lin-Manuel Miranda, Emma Stone to Host 2020 Met Gala

    Besides nabbing Streep, the upcoming event marks a landmark 150th anniversary for the museum. The museum described its choice as a reflection on the ephemeral nature of fashion.
    Michael Bloomberg Considers Entering Presidential Race

    Michael Bloomberg Considers Entering Presidential Race

    However, the Times said the 77-year-old has yet to officially make up his mind about seeking the highest office in the land.
    Trump denies asking attorney general to clear him on Ukraine

    Trump denies asking attorney general to clear him on Ukraine

    CBS News has learned the White House is bringing in reinforcements to help fight the House impeachment inquiry PR battle. Kent, along with William Taylor - the top US diplomat in Ukraine - will testify publicly on November 13.

We are pleased to provide this opportunity to share information, experiences and observations about what's in the news.
Some of the comments may be reprinted elsewhere in the site or in the newspaper.
Thank you for taking the time to offer your thoughts.